95% specific with canalicular pattern ( am j surg pathol 2001;25:1297 , am j surg pathol 2002;26:978 ), although another study recommends use of hepatocyte, moc31 and pcea but not cd10 ( mod pathol 2002;15:1279 ) mesothelioma (malignant): ● diffuse malignant mesothelioma has patchy, moderately intense cytoplasmic cd10 staining versus intense cytoplasmic and membranous cd10 staining in metastatic renal cell carcinoma ( arch pathol lab med 2006;130:823 ) microvillous inclusion disease: ● strong cd10+ cytoplasmic staining vs. order viagra online viagra samples where can i get free viagra samples viagra women safety Linear brush border staining in normals ( am j surg pathol 2002;26:902 ) multiple myeloma: ● cd10+ and lack of light chain isotype suppression (suppression of normal immunoglobulins containing the light chain of the same isotype as the abnormal paraprotein) in blood lymphocytes are early markers of progressive disease ( br j haematol 1987;67:39 ) pancreas: ● solid and pseudopapillary tumor is cd10+ ( am j surg pathol 2000;24:1361 ) ● differentiates mucinous cystic neoplasms (cd10+/ck20+) from intraductal papillary mucinous neoplasm of branch duct type (cd10-/ck20-) ( pancreas 2009;38:558 ) ● in pancreatic neuroendocrine tumors, cd10 expression is associated with poor survival, large tumor size, high ki-67 index, metastases ( hum pathol 2006;37:802 ) skin tumors: ● differentiates trichoblastomas with peritumoral stromal staining and basal cell carcinomas with epithelial staining; if stroma and epithelial areas are cd10+, suggests basal cell carcinoma with follicular differentiation ( int j dermatol 2009;48:713 ) ● differentiates atypical fibroxanthoma (diffuse membranocytoplasmic staining) from spindle cell melanoma and sarcomatoid squamous cell carcinoma (cd10-, j cutan pathol 2010;37:744 ) vascular tumors: ● differentiates hemangioblastoma (cd10-) from metastatic renal cell carcinoma (cd10+, mod pathol 2005;18:788 ) ● epithelioid hemangioendothelioma can be strong/diffuse cd10+ and mimic metastatic renal cell carcinoma ( arch pathol lab med 2009;133:1965 ) interpretation ========================================================================= ● apical surface only: malignant glandular cells of well-differentiated colonic, pancreatic and prostatic adenocarcinoma ●. viagra women safety cheap generic viagra non prescription viagra canada where to buy generic viagra viagra women safety viagra cost generic viagra online viagra for sale cheap


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